This medicine is a stimulant combination used to treat attention-deficit hyperactivity disorder (ADHD). It also is used to treat narcolepsy (sudden and uncontrollable attacks of drowsiness and sleep). This medicine may also be used to treat other conditions as determined by your doctor.
Follow the directions for using this medicine provided by your doctor. This medicine comes with a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully each time you refill this medicine. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. This medicine may be taken on an empty stomach or with food. TAKE YOUR LAST DOSE OF THE DAY 4 to 6 hours before bedtime unless your doctor tells you differently. CERTAIN FOODS AND MEDICINES can affect the amount of acid in your stomach and intestines. This can increase or decrease (depending on the medicine) the absorption of this medicine. DO NOT TAKE ANTACIDS (eg, calcium carbonate) or certain alkalinizing agents (eg, sodium bicarbonate) with this medicine without first talking with your doctor. They may increase the risk of side effects of this medicine. Tell your doctor if you take any of these products: fruit juice, ascorbic acid (vitamin C), ammonium chloride, sodium acid phosphate, ulcer medicines (eg, H2 blockers, such as famotidine and ranitidine; proton pump inhibitors / PPIs, such as omeprazole and lansoprazole), methenamine, or acetazolamide. STORE THIS MEDICINE at room temperature, 77 degrees F (25 degrees C), in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. KEEP THIS MEDICINE out of the reach of children and away from pets. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
WARNING: This medicine has a high potential for abuse and may be habit forming if used for a long period of time. Use this medicine only as prescribed and do not share it with others. Abuse of this medicine may cause serious heart problems, blood vessel problems, or sudden death. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking furazolidone, guanadrel, guanethidine, or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or if you have taken furazolidone or an MAOI within the last 14 days. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking alkalinizing agents (eg, sodium bicarbonate, acetazolamide), alpha-blockers (eg, prazosin), antacids (eg, calcium carbonate), antihistamines (eg, diphenhydramine), beta-blockers (eg, metoprolol), decongestants (eg, pseudoephedrine), ethosuximide, glutamic acid, haloperidol, lithium carbonate, meperidine, phenobarbital, phenothiazines (eg, chlorpromazine), phenytoin, proton pump inhibitors (PPIs) (eg, lansoprazole, omeprazole), propoxyphene, reserpine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), sympathomimetic medicines (eg, albuterol), tramadol, tricyclic antidepressants (eg, desipramine), urinary acidifiers (eg, methenamine, ammonium chloride), or vitamin C (ascorbic acid). Tell your doctor if you are taking medicines for high blood pressure or other medicines for ADHD. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of seizures or abnormal electroencephalograms (EEGs), liver or kidney problems, growth problems, thyroid problems, uncontrolled muscle movements (eg, tics), Tourette syndrome, anorexia, the blood disease porphyria, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a personal or family history of mental or mood problems (eg, agitation, anxiety, bipolar disorder, depression, psychosis, tension), abnormal thoughts, hallucinations, suicidal thoughts or attempts, or alcohol or other substance abuse or dependence. Tell your doctor if you have a history of heart problems (eg, heart failure, heart defects, fast or irregular heartbeat), recent heart attack, high blood pressure, hardening of the arteries, or blood vessel problems or if a family member has a history of any of these problems or sudden death. Tell your doctor if you participate in strenuous exercise or activities. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe hardening of the arteries; active heart or blood vessel disease; moderate, severe, or uncontrolled high blood pressure; an overactive thyroid; glaucoma; agitation, anxiety, or tension; or serious heart problems (eg, heart defect, irregular heartbeat). USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of alcohol or other substance abuse. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
SIDE EFFECTS that may occur while taking this medicine include constipation; diarrhea; dizziness; dry mouth; headache; loss of appetite; nausea; nervousness; restlessness; stomach pain or upset; trouble sleeping; unpleasant taste; vomiting; weakness; or weight loss. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience blurred vision or other vision problems; change in sexual ability or desire; chest, jaw, or arm pain; confusion; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; new or worsening mental, mood, or behavior problems (eg, abnormal thoughts, aggression, agitation, anxiety, delusions, depression, hostility); one-sided weakness; painful or frequent urination; red, swollen, peeling, or blistered skin; seizures; severe or persistent headache; severe stomach pain; severe weight loss; shortness of breath; sudden, severe nausea or vomiting; slurred speech; uncontrolled muscle movement; unusual sweating; or unusual weakness or tiredness. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include confusion; fainting; fast breathing; fever; hallucinations; irregular heartbeat; mental or mood changes (eg, depression); muscle pain or tenderness; overactive reflexes; seizures; severe nausea, vomiting, diarrhea, or stomach cramps; severe or persistent headache or dizziness; severe restlessness; tremor; or unusual tiredness.
IF YOU ARE TAKING THIS MEDICINE for ADHD and your symptoms do not improve or if they become worse, check with your doctor. WHEN USED FOR ADHD, this medicine should be used as part of an ADHD treatment program that includes a variety of treatment measures (eg, psychological, educational, social). DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain a new prescription from your doctor before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.