This medicine is a multi-kinase enzyme inhibitor used to treat advanced cancer of the kidney. It is also used to treat certain types of liver cancer. It may also be used to treat other conditions as determined by your doctor.
Follow the directions for using this medicine provided by your doctor. An additional patient information leaflet is available with this medicine. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. SWALLOW WHOLE. Do not break, crush, or chew before swallowing. TAKE THIS MEDICINE ON AN EMPTY STOMACH at least 1 hour before or 2 hours after eating. Take this medicine with a full glass of water (8 oz/240 mL). STORE THIS MEDICINE at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), away from heat, moisture, and light. KEEP THIS MEDICINE out of the reach of children and away from pets. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same times each day will help you to remember. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking barbiturates (eg, phenobarbital, primidone), carbamazepine, dexamethasone, docetaxel, doxorubicin, fluorouracil/leucovorin, hydantoins (eg, fosphenytoin, phenytoin), irinotecan, nevirapine, oral neomycin, rifamycins (eg, rifabutin, rifampin), St. John's wort, or warfarin. Tell your doctor if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including bleeding problems, active bleeding, heart failure or other heart problems (eg, disease of the blood vessels in the heart, recent heart attack, slow or irregular heartbeat), chest pain, high blood pressure, liver or kidney problems, blood electrolyte problems (eg, low blood calcium, magnesium or potassium levels), allergies, pregnancy, or breast-feeding. Tell your doctor if you are on dialysis, if you have or are being treated for lung cancer, or if you have had or will be having surgery or a dental procedure. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a certain type of lung cancer (squamous cell) and are taking carboplatin and paclitaxel. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a certain type of irregular heartbeat (congenital long QT syndrome). Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
SIDE EFFECTS that may occur while taking this medicine include constipation; dry skin; headache; nausea; vomiting; diarrhea; loss of appetite; mouth, bone, muscle, stomach, or joint pain; weakness; tiredness; hair thinning or loss; or weight loss. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience black or tarry stools; fever, chills, or persistent sore throat; chest, jaw, or left arm pain; confusion; decreased sexual ability; decreased urination; depression; fainting; fast or irregular heartbeat; mouth sores; one-sided weakness; red, swollen, blistered, or peeling skin; redness, pain, swelling, numbness, tingling, ulcers, or blisters on the palms of the hands or soles of the feet; severe or persistent dizziness, headache, or lightheadedness; shortness of breath; coughing up or vomiting blood; speech changes; seizures; sudden increased sweating; sudden weight gain; swelling of the ankles, hands, or feet; severe stomach pain, vomiting, or nausea; symptoms of liver problems (eg, dark urine, unusual loss of appetite, pale stools, yellowing of the eyes or skin); unusual bruising or bleeding; numbness or tingling in the arm or leg; unusual tiredness or weakness; vision changes; or vomit that looks like coffee grounds. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include rash, redness, swelling, blistering, or itching of skin; or severe or persistent diarrhea.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF YOU WILL BE USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.