This medicine is a fast-acting form of the hormone insulin used for treating diabetes mellitus. This medicine is usually used with a longer-acting insulin or insulin pump therapy.
Follow the directions for using this medicine provided by your doctor. AN EXTRA PATIENT LEAFLET is available with this medicine. Talk to your pharmacist if you have questions about this information. USE THIS MEDICINE within 5 to 10 minutes before a meal unless directed otherwise by your doctor. IF YOU WILL BE USING THIS MEDICINE AT HOME, a health care provider will teach you how to use it. Be sure you understand how to use this medicine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. YOU MAY USE THIS MEDICINE IN AN INSULIN PUMP if you are directed to do so by your doctor. If you are using an insulin pump, do NOT dilute this medicine or mix it together with any other type of insulin. This medicine should be clear and colorless. DO NOT USE THIS MEDICINE IF IT CONTAINS particles, is cloudy, thickened, or discolored, or if the vial or container is cracked or damaged. IF YOU ARE MIXING THIS MEDICINE WITH NPH INSULIN, draw this medicine into the syringe first. Inject the dose immediately after mixing, as directed by your doctor. DO NOT MIX this medicine with any other type of insulin. USE THE PROPER TECHNIQUE taught to you by your doctor. Inject deep under the skin, NOT into a vein or muscle. INJECTION SITES within an injection area (abdomen, buttock, thigh, upper arm) must be rotated from one injection to the next. DO NOT INJECT medicine into skin that is red, swollen, or itchy. BE SURE YOU HAVE PURCHASED THE CORRECT INSULIN. Insulin comes in a variety of containers including vials, cartridges, and pens. Make sure that you understand how to properly measure and prepare your dose. DO NOT SHARE pen or cartridge devices with another person. Sharing these devices may pass infections from one person to another. This includes infections you may not know you have.THIS MEDICINE BEGINS LOWERING BLOOD SUGAR WITHIN 10 to 20 minutes after an injection. The peak effect occurs within 1 to 3 hours after a dose. The effect lasts for up to 3 to 5 hours. STORE NEW (UNOPENED) vial, cartridge systems, or prefilled syringes in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). STORE USED (OPEN) VIALS either in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), or at room temperature, below 86 degrees F (30 degrees C). STORE USED (OPEN) CARTRIDGE SYSTEMS OR PREFILLED SYRINGES at room temperature, below 86 degrees F (30 degrees C). Do NOT store used (open) cartridges or prefilled syringes in the refrigerator. Store away from heat and light. If this medicine has been frozen or overheated, throw it away. Throw away unrefrigerated or opened vials after 28 days, even if they still contain medicine. Throw away unrefrigerated or used cartridge systems or prefilled syringes after 28 days, even if they still contain medicine. Avoid temperatures above 98.6 degrees F (37 degrees C). Do not leave this medicine in a car on a warm or sunny day. Do not use this medicine after the expiration date stamped on the label. It is very important to follow your insulin regimen exactly. DO NOT MISS any doses of insulin. Ask your doctor for specific instructions to follow in case you should ever miss a dose of insulin.
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking beta-blockers (eg, propranolol); clonidine; guanethidine; lithium; reserpine; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril); disopyramide; fenfluramine; fibrates (eg, clofibrate, gemfibrozil); fluoxetine; monoamine oxidase inhibitors (MAOIs) (eg, phenelzine); oral medicines for diabetes (eg, glipizide, metformin, nateglinide); pentamidine; pramlintide; propoxyphene; salicylates (eg, aspirin); somatostatin analogs (eg, octreotide); sulfonamide antibiotics (eg, sulfamethoxazole); atypical antipsychotics (eg, olanzapine); corticosteroids (eg, prednisone); danazol; diuretics (eg, furosemide, hydrochlorothiazide); estrogen; hormonal contraceptives (eg, birth control pills); isoniazid; niacin; phenothiazines (eg, chlorpromazine); progesterones (eg, medroxyprogesterone); somatropin; sympathomimetics (eg, albuterol, epinephrine, terbutaline); or thyroid hormones (eg, levothyroxine). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including if you have kidney or liver problems; nerve problems; adrenal, pituitary, or thyroid problems; diabetic ketoacidosis; blood electrolyte problems (eg, high blood sodium levels, low blood potassium levels); allergies; pregnancy; or breast-feeding. Tell your doctor if you drink alcoholic beverages, smoke, use 3 or more insulin injections per day, are fasting, are on a low-salt diet, or you exercise. USE OF THIS MEDICINE IS NOT RECOMMENDED if you are having an episode of low blood sugar. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
SIDE EFFECTS that may occur while taking this medicine include redness, swelling, itching, or mild pain at the injection site; or weight gain. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience burning, numbness, or tingling of your arms, hands, legs, or feet; changes in vision; chills; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; mental or mood changes; muscle pain, weakness, or cramping; seizures; slurred speech; swelling; tremor; trouble concentrating; unusual hunger; unusual sweating; or weakness. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or wheezing. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include chills; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; nervousness; seizures; shakiness; sweating; tremor; vision changes; or weakness.
DO NOT USE MORE THAN THE RECOMMENDED DOSE, use this medicine more often than prescribed, or change the type or dose of insulin you are using without checking with your doctor. ANY CHANGE OF INSULIN should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (beef, pork, beef-pork, human), and/or method of manufacture may require a change in dose. CARRY AN ID CARD at all times that says you have diabetes. CHECK WITH YOUR DOCTOR IF you notice a depression in the skin or skin thickening at the injection site. You may need to change your injection technique. PROPER DIET, regular exercise, and regular testing of blood sugar are important for best results when using this medicine. Tell your doctor if you have had a recent change in diet or physical activity. YOU AND YOUR DOCTOR SHOULD ESTABLISH A SICK DAY PLAN to use in case of illness. When you are sick, test your blood/urine frequently and call your doctor as instructed. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children and pets. Do NOT reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain more insulin before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.