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Progesterone Coupon & Discounts

Save on Progesterone at your pharmacy with the free discount below.

Progesterone pills or creams are needed for many women passing through different phases of life. The progesterone hormone is used in medication form to treat symptoms of menopause as well as to sustain pregnancy and control menstrual cycles. It is also used in most hormonal contraceptives. The cost of regularly ... Read more

Progesterone Discount

Savings with HelpRx discount up to:

71% Off

on Progesterone

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*The discount percent is an estimate based off recent cardholder data. Valid as of May 26, 2018

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Progesterone Information:

What is progesterone?

Progesterone is known primarily as a female steroid hormone, but it is also produced by the male body. It plays a greater role in women’s bodies by regulating the female reproductive system and menstrual cycle. It also plays a key role in sustaining pregnancy. Progesterone has effects on the nervous system as well. Progesterone levels have shown a positive correlation with levels of serotonin and GABA neurotransmitters which may be one of the reasons why PMDD and menopause can cause mood swings. Progesterone is commonly prescribed along with estrogen as an oral or topical medication to treat women who are experiencing menopausal symptoms. It balances the effects of estrogen and prevents endometrial hyperplasia, a proliferation of cells in the lining of the uterus. These rapidly changing and growing cells are susceptible to becoming cancerous. It is also sometimes administered vaginally to promote and sustain pregnancy. Progesterone pills and creams are either synthesized or made from plant or animal progesterone.

How do I take progesterone?

Oral progesterone pills are usually taken once a day in the evenings. Progesterone should usually be taken for just part of the month to mimic your body’s natural cycle. Follow your doctor’s instructions exactly. Progesterone is easily absorbed through the skin and is sometimes the preferred method for taking progesterone. Progesterone creams may be purchased over-the-counter, but they may not always contain the recommended amount of progesterone. Some over-the-counter progesterone creams have been found to be incorrectly labeled. Talk to your doctor about which progesterone cream is best for you. The recommended amount of progesterone in a cream is 3% by volume.

Before taking progesterone, tell your doctor if:

  • You are taking prescription or nonprescription drugs, vitamins, or supplements, especially hormonal contraceptives, St. John’s Wort, other hormone therapies, amiodarone, antifungals, antibiotics, HIV medications, antidepressants, medications for treating GERD or stomach acid, verapamil, and zafirlukast.
  • You have a history of unexplained vaginal bleeding, miscarriage, breast cancer or other cancers of the reproductive system.
  • You are allergic to progesterone, contraceptives, or peanuts.
  • You have a history of seizures or migraine headaches.
  • You have experienced a stroke or blood clots.
  • You are pregnant or breast-feeding.
  • You have diabetes, asthma, or depression.
  • You have a history of kidney, heart, liver, or gallbladder disease.
  • You drink grapefruit juice.

What are the possible side effects of taking progesterone?

Side effects from taking progesterone include mood swings, fatigue, irritability, headaches-especially migraines, upset stomach, nervousness or increased worrying, constipation, gas or indigestion, acne, breast enlargement, cramping or uterine spasms, breast pain, vaginal bleeding, and vaginal discharge. Some side effects can be serious. Report any serious side effect to your doctor immediately including swelling, change in heart rate, migraines, breast lumps, unusual bleeding, seizures, shaking, chest pain, depression, and a change in vision.

What if I forget to take a dose of progesterone?

If you miss a dose of progesterone, take the missed dose as soon as you remember.  If it’s almost time for your next dose, skip the missed dose and continue on your regular schedule. Do not take a double dose to compensate. 

How do I store progesterone?

Most progesterone creams and pills and be safely stored between 68 and 77 degrees Fahrenheit. Check with your pharmacist to be sure how to store your particular form of progesterone. Keep your medication tightly closed and out of reach of children.

What happens if I overdose on progesterone?

Overdosing on progesterone is not likely as it is a naturally-occurring hormone in the body and is well-tolerated. Excessive use of progesterone can result in fatigue, swelling or water retention, and feeling sluggish. If you experience a serious symptom and you think you have overdosed, contact the Poison Control Center at 1-800-222-1222. If you think you are taking too much progesterone, contact your doctor.


Progesterone may make you dizzy or drowsy. It is best to take this medication at bedtime. Do not drive or operate heavy machinery until you know your tolerance to this mediation. Get up slowly from a reclining position to avoid dizziness. Progesterone may cause blood clotting. Talk to your doctor about the risks of taking progesterone.

Brand Names

Brand names for products containing progesterone include Prometrium, Prempro, and Premphase. Get up to 70% off the progesterone retail cost when you use our free coupons at your local pharmacy. Also search for coupons for brand-name progesterone products on HelpRx and get up to 80% off the retail cost.

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Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.