This medicine is a mu-receptor antagonist used to treat constipation caused by opioid medicines in certain patients. It may also be used to treat other conditions as determined by your doctor.
Follow the directions for taking this medicine provided by your doctor. An extra patient leaflet is available with this medicine. Talk to your pharmacist if you have questions about this information. This medicine is given as an injection under the skin. A health care provider will teach you how to use it. Be sure you understand how to use this medicine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. This medicine is colorless to pale yellow in color. Do NOT use this medicine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. Inject this medicine right after you draw it into the syringe. If you are not able to inject the medicine right away, it may be stored in the syringe at room temperature for up to 24 hours. You do not need to protect the syringe from light during this time. This medicine may be injected into the upper arm, abdomen, or thigh. Do NOT inject this medicine into the upper arm if you are injecting yourself. Rotate injection sites as directed by your health care provider. Do not inject into scars, stretch marks, or areas where the skin is bruised, tender, red, or hard. Do NOT use this medicine more often than 1 time in a 24-hour period unless your doctor tells you otherwise. Do NOT use a vial of this medicine more than 1 time, even if there is medicine left in the vial. STORE THIS MEDICINE at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. KEEP THIS MEDICINE, as well as syringes and needles, out of reach of children and away from pets. IF YOU MISS A DOSE of this medicine and you are still constipated, use it as soon as you remember. Continue to use it as directed by your doctor. Do not use more than 1 dose within a 24-hour period.
SOME MEDICINES MAY INTERACT with this medicine. ASK YOUR HEALTH CARE PROVIDER if this medicine may interact with other medicines you take. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including nausea, vomiting, stomach pain or swelling, certain other stomach or bowel problems (eg, cancer, ulcer, Ogilvie syndrome), allergies, pregnancy, or breast-feeding. Tell your doctor if you are on dialysis, you have a peritoneal (abdominal) catheter, or you have a history of kidney or liver problems. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have known or suspected stomach or bowel blockage. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
SIDE EFFECTS that may occur while taking this medicine include: dizziness; gas; mild diarrhea; nausea; stomach pain; sweating; vomiting. If they continue or are bothersome, check with your doctor. SEEK MEDICAL ATTENTION RIGHT AWAY if any of these SEVERE side effects occur: fever or chills; new or worsening nausea or vomiting; severe, persistent, or worsening diarrhea, nausea, vomiting, or stomach pain. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe dizziness, fainting, fatigue, or weakness.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full.