This medicine is an antifibrinolytic agent used to reduce or prevent excessive bleeding and reduce the need for blood clotting factor transfusions during or after tooth extractions in patients with hemophilia. It is also used to prevent or reduce bleeding during certain medical procedures (eg, cervical surgery) and to treat certain bleeding problems (eg, nosebleeds, bleeding inside the eye, heavy menstrual periods) in patients whose blood does not clot well. It is also used to treat hereditary angioneurotic edema. It may also be used for other conditions as determined by your doctor.
Follow the directions for using this medicine provided by your doctor. This medicine may be administered as an injection at your doctor's office, hospital, or clinic. This medicine is sometimes used at home as an injection. If you are using this medicine at home, a healthcare professional will provide detailed instructions for its appropriate use. Ask any questions that you may have about this medicine or giving injections. IF THIS MEDICINE CONTAINS PARTICLES OR IS DISCOLORED, or if the vial is cracked or damaged in any way, do not use it. STORE THIS MEDICINE as directed on the prescription label. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children and pets. CONTINUE TO USE THIS MEDICINE for the full course of treatment even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor for further instructions.
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT USE THIS MEDICINE if you are also using medicine to help your blood clot (eg, factor IX complex concentrates or anti-inhibitor coagulant concentrates). ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (eg, warfarin), desmopressin, hormonal birth control (eg, birth control pills), hydrochlorothiazide, nitroglycerin, ranitidine, sulbactam-ampicillin, or tretinoin (all-trans retinoic acid). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of kidney problems, diabetes, polycystic ovary syndrome, bleeding or blood clotting problems, a certain other blood problem (disseminated intravascular coagulation / DIC), bleeding in the brain, eye or vision problems, allergies, pregnancy, or breast-feeding. Tell your doctor if you are overweight, take estrogen or tamoxifen, or if you have a personal or family history of blood clots or endometrial cancer. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have blood clots (eg, in the leg, lung, eye, brain), a history of blood clots, or you have conditions that may increase your risk for blood clots (eg, certain heart valve problems, certain types of irregular heartbeat, certain blood clotting problems). This medicine is also not recommended if you have bleeding in the brain, blood in the urine, bleeding related to kidney problems, irregular menstrual bleeding of unknown cause, or a disturbance of color vision. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
SIDE EFFECTS that may occur while using this medicine include nausea, vomiting, or diarrhea. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience calf or leg pain, swelling, or tenderness; chest pain; confusion; coughing up blood; decreased urination or difficulty urinating; eye problems; fainting; numbness of an arm or leg; one-sided weakness; redness, pain or swelling at the injection site; seizures; severe or persistent dizziness or lightheadedness; shortness of breath; slurred speech; sudden, severe headache or vomiting; or vision changes or problems (eg, disturbance of color vision, sharpness, or field of vision). AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest or throat; or swelling of the mouth, face, lips, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness upon standing; fainting; lightheadedness; mental or mood changes; muscle twitching; rash; seizures; severe diarrhea, nausea, or vomiting; or vision problems.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.