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Controlled substance

Trezix Coupon & Discounts

Save on Trezix at your pharmacy with the free discount below.

Trezix is a prescription oral medication for adults 18 years of age or older that treats moderate to severe pain. Available in a capsule formulation, the average cost for Trezix 320.5mg/30mg/16mg is around $100 for a bottle containing 30 capsules, and it may vary by pharmacy location. HelpRx currently has a dru ... Read more

Trezix Discount

Savings with HelpRx discount up to:

75% Off

on Trezix

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*The discount percent is an estimate based off recent cardholder data. Valid as of May 22, 2018

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Trezix Information:

What is Trezix?

Trezix is a drug that treats adult patients 18 years of age with moderate to severe pain. Trezix contains three active ingredients, acetaminophen, caffeine, and dihydrocodeine that work in combination to reduce pain that can be cause by medical conditions such as arthritis.  

How do I take Trezix?

Dosage may vary depending on the clinical profile of the patient, but typically adults should take 2 Trezix capsules orally every 4 hours as needed. Patients on Trezix should not exceed 2 capsules in a 4 hour period or more than 10 capsules in a 24 hour period. Patients are recommended to take Trezix with food to avoid nausea or irritation of the stomach. 

Before taking Trezix, tell your doctor if:

  • You are pregnant or plan to become pregnant
  • You are taking any medications of supplements containing acetaminophen
  • You have a history of alcohol or drug abuse
  • You have a history of asthma
  • You have recently had stomach or bowel surgery 

What are the possible side effects of taking Trezix?

The most common side effects patients take Trezix experience are light headedness, dizziness, drowsiness, headache, fatigue, sedation, sweating, nausea, vomiting, constipation, and skin reactions like itching, and trouble urinating. Take Trezix as directed to avoid these possible adverse effects. 

What if forget to take a dose of Trezix?

If you miss a dose of Trezix, take the next dose 4 hours after the missed dose. Patients should only take Trezix when pain relief is needed to avoid a drug dependency. 

How do I store Trezix? 

Store the bottle of Trezix in a cool place with a temperature between 68°F to 77°F. Avoid storing Trezix in places with moisture as it may alter the chemical composition of the active ingredients. Keep Trezix out of reach from children and pets, as it can be hazardous if consumed.  

What happens if I overdose on Trezix?

Of the three active ingredients in Trezix, acetaminophen and dihydrocodeine can cause toxicity in the body that requires immediate medical attention. Some of the symptoms of a Trezix overdose include general pain discomfort, trouble breathing, nausea, vomiting, and sweating. If you or someone else overdoses on Trezix, contact poison control immediately at 1-800-222-1222. If the person has lost consciousness or stopped breathing, contact local emergency services at 911.


High doses of acetaminophen over 4000 milligrams per day can cause acute liver failure that can lead to death. Dihydrocodeine can cause severe respiratory depression, so it is important that individuals with obstructive sleep apnea take Trezix carefully according to doctor’s recommendations. Patients with a history of substance abuse should note that dihydrocodeine is very addictive and it could lead to drug dependence if not taken as directed. 

Brand Names

Trezix is an off-brand of Synalgos-DC, which is no longer available on the market. To keep prescription costs low, use the Trezix coupon available on our site that can reduce the pharmacy retail price by up to 75% off. HelpRx also has a discount card that can save patients 75% off hundreds of other generic and brand name medications. To download, print, or email this savings offer, click the ‘Free Card’ button on the top right corner of the HelpRx site.

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“The price for my prescription has gone up the past year and paying the out of pocket cost was getting increasingly difficult. Now, through HelpRx I’ve saved hundreds! Thank you HelpRx” - Janet Larsen - Austin, TX

Trezix Information:

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About Our Savings: is a discount pharmacy service, partnered with a leading pharmacy benefit manager. We negotiate lower prices on prescription medications, that we pass on to our members for free. There is no cost to use our cards and coupon, and anyone can take advantage of our discounts, regardless of healthcare coverage.

Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.