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Activella Coupon & Discounts

Save on Activella at your pharmacy with the free discount below.

Activella is a drug prescribed to treat moderate to severe symptoms of menopause, including vaginal atrophy, hot flashes and the prevention of osteoporosis. Activella costs around $230 for thirty tablets, which is a month’s supply. To help lower the price of Activella if your insurance doesn’t cover ... Read more

Activella Discount

Savings with HelpRx discount up to:

75% Off

on Activella

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*The discount percent is an estimate based off recent cardholder data. Valid as of May 25, 2018

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Activella Information:

What is Activella?

Activella is a pill with ingredients similar to those in hormonal birth control, estradiol (estrogen) and norethindrone (progestin), but it contains a much higher dose of estrogen. This is why other medications should be considered for menopausal symptoms, such as topical vaginal medications and non-estrogen options before prescribing Activella. 

How do I take Activella?

Activella should be taken once daily at the same time every day, and can be taken with or without food. Always follow your doctor’s dosing instructions. They may vary based on your condition. Your doctor should re-evaluate your condition periodically to see if the medication can be discontinued.

Before taking Activella, tell your doctor if:

  • You smoke cigarettes.
  • You have ever had breast cancer or any cancer of the reproductive system.
  • You have ever had a stroke or heart attack.
  • You have ever had a blood clot or are taking blood thinners.
  • You have high cholesterol levels.
  • You have diabetes or lupus.
  • You have dementia or another mental condition.
  • You have recently had an irregular mammogram or PAP test.
  • You are allergic to any of the ingredients in this medication.
  • You have liver or kidney disease.
  • You have thyroid problems.
  • You are taking any other prescription or nonprescription medications, especially birth control pills, hormonal medications or injections, antifungals, blood thinners, antibiotics, antidepressants, antivirals, thyroid medications, blood pressure or heart medications and St. John’s wort.
  • You get migraine headaches.
  • You have asthma or you experience seizures.

What are the possible side effects of taking Activella?

Possible side effects from taking Activella include breast pain and tenderness, bloating, nausea, vomiting, headache and weight changes. If any of these side effects are drastic or severe, tell your doctor as soon as possible. More serious side effects that require immediate attention include memory loss, negative mood changes, breast lumps, unusual vaginal bleeding, yellowing skin or eyes, severe abdominal pain, worsening symptoms such as increased vaginal irritation, swelling of the hands, feet or ankles; unquenchable thirst and increased urination.

This medication can increase your risk of developing blood clots and having a stroke or heart attack. Signs of this include: pain in your left arm, jaw or chest; unusual perspiration, severe headache, weakness or numbness on one side of the body, confusion, slurred speech; pain, swelling, tingling or numbness in the arms or legs; sudden vision changes, trouble breathing and severe dizziness or fainting. Seek medical attention immediately if any of these symptoms occur.

What if I forget to take a dose of Activella?

If you miss a dose of Activella, take the missed dose as soon as your remember. If it’s almost time for your next dose, skip the missed dose and continue on your regular regimen. Do not take a double dose or consecutive doses of Activella to try to compensate for a missed one. 

How do I store Activella?

Store Activella in a cool, dry place, preferably at a temperature between 68 and 77 degrees Fahrenheit. Keep this medication out of direct light and away from children and pets.

What happens if I overdose on Activella?

Signs of Activella drug overdose include vomiting, abdominal pain, breast pain, fatigue and vaginal bleeding. If you think you are taking too much of this medication, ask your doctor about changing your dose. If you or someone else accidentally ingests an excessive amount of Activella at once, call the Poison Control Center at 1-800-222-1222.


Medications containing estrogen, especially in higher doses like Activella, can increase your risk of developing endometrial cancer, breast cancer or blood clots. It also increases the risk of stroke and heart attack. Do not smoke while using this medication. This further increases the risk of developing these conditions.

Brand Names

The generic name for Activella is estradiol/norethindrone. Other brand names for treating menopause include Mimvey, Lopreeza, Angeliq, Prempro, Premphase and Estrace or Femtrace (estrogen only). Search HelpRx for drug coupons for Activella or any of these similar medications to cut your monthly medication costs.

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About Our Savings: is a discount pharmacy service, partnered with a leading pharmacy benefit manager. We negotiate lower prices on prescription medications, that we pass on to our members for free. There is no cost to use our cards and coupon, and anyone can take advantage of our discounts, regardless of healthcare coverage.

Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.