This medicine is an angiotensin converting enzyme (ACE) inhibitor and thiazide diuretic combination used to treat high blood pressure. It may also be used to treat other conditions as determined by your doctor.
Follow the directions for using this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. IF YOU TAKE CHOLESTYRAMINE OR COLESTIPOL, ask your doctor or pharmacist how to take it with this medicine. STORE THIS MEDICINE at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. KEEP THIS MEDICINE out of the reach of children and away from pets. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same time each day will help you to remember. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
WARNING: This medicine may cause injury or even death to the fetus if taken during pregnancy. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking dofetilide or ketanserin. DO NOT TAKE THIS MEDICINE if you are also taking aliskiren and you have either diabetes or kidney problems. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking aliskiren, angiotensin receptor blockers (eg, losartan), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen, celecoxib), diuretics (eg, furosemide), eplerenone, potassium-sparing diuretics (eg, amiloride, spironolactone), insulin or other medicines for diabetes (eg, glipizide, metformin), certain gold-containing medicines (eg, sodium aurothiomalate), lithium, potassium supplements, salt substitutes containing potassium, thiopurines (eg, azathioprine), diazoxide, digitalis glycosides (eg, digoxin), barbiturates (eg, phenobarbital), adrenocorticotropic hormone (ACTH), corticosteroids (eg, prednisone), dextran sulfate, everolimus, sirolimus, trimethoprim, narcotic pain medicines (eg, codeine), or other medicines for high blood pressure. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including heart problems (eg, heart failure); blood vessel problems (eg, in the brain or heart); blood electrolyte problems (eg, high blood potassium levels); an autoimmune disease (eg, lupus, scleroderma); bone marrow suppression; high blood cholesterol or lipid levels; severe immune system problems; gout; low blood sodium levels; low blood volume; dehydration; diabetes; allergies; pregnancy or if you are able to become pregnant; or breast-feeding. Tell your doctor if you have a history of asthma, liver problems, kidney problems (eg, renal artery stenosis), or a kidney transplant. Tell your doctor if you are on a low-salt (sodium) diet, if you are scheduled to have surgery or to receive anesthesia, if you are on dialysis, if you recently had a certain type of nerve surgery (sympathectomy), or if you have never taken another medicine for high blood pressure. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor. USE OF THIS MEDICINE IS NOT RECOMMENDED if you are unable to urinate or if you are pregnant. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
SIDE EFFECTS that may occur while taking this medicine include nausea; vomiting; diarrhea; headache; persistent, dry cough; dizziness; lightheadedness; or tiredness. If they continue or are bothersome, check with your doctor. THIS MEDICINE MAY RAISE YOUR BLOOD SUGAR. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. THIS MEDICINE CONTAINS A SULFONAMIDE CALLED HYDROCHLOROTHIAZIDE, which can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (eg, sulfamethoxazole) or to penicillin antibiotics (eg, amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting this medicine. Contact your doctor if you experience symptoms such as vision changes (eg, decreased vision clearness) or eye pain. CONTACT YOUR DOCTOR IMMEDIATELY if you experience burning, numbness, or tingling of the skin; chest pain; confusion; decreased, difficult, or painful urination; dry mouth; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; mental or mood changes; muscle cramps, pain, or weakness; red, swollen, blistered, or peeling skin; restlessness; seizures; severe dizziness, drowsiness, or lightheadedness; severe or persistent nausea or vomiting; shortness of breath; sluggishness; stomach pain (with or without nausea or vomiting); unusual bruising or bleeding; unusual thirst, tiredness, or weakness; or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the hands, mouth, face, lips, eyes, throat, or tongue; or unusual hoarseness. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness, fainting, and weakness.
PATIENTS WHO TAKE MEDICINE FOR HIGH BLOOD PRESSURE often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.