This medicine is a bisphosphonate used to treat high blood calcium levels caused by cancer. It is also used with other medicines to treat patients with certain types of cancer. It may also be used to treat other conditions as determined by your doctor.
Follow the directions for using this medicine provided by your doctor. THIS MEDICINE IS USUALLY ADMINISTERED AS AN INFUSION at your doctor's office, hospital, or clinic. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine. IF YOU ARE USING THIS MEDICINE AT HOME, a healthcare professional will provide detailed instructions for its appropriate use. Ask them any questions that you may have about your medicine or giving injections. If the medicine contains particles or if the container is cracked or damaged in any way, do not use it. This medicine is usually handled and stored by a health care provider. IF YOU ARE USING THIS MEDICINE AT HOME, store this medicine as directed by your pharmacist or health care provider. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children and pets. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor to establish a new dosing schedule.
Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking another medicine that contains zoledronic acid or any other bisphosphonate (eg, alendronate). ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are also taking corticosteroids (eg, prednisone), loop diuretics (eg, furosemide), or medicines that may harm the kidney (eg, aminoglycosides, such as gentamicin; amphotericin B; cyclosporine; non-steroidal anti-inflammatory drugs / NSAIDs, such as ibuprofen; tacrolimus; vancomycin). If you are unsure if any medicine you are taking might harm the kidney, ask your doctor or pharmacist. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including kidney problems, dehydration, low blood volume, cancer, poor dental hygiene or other dental problems, an upcoming dental procedure (eg, tooth extraction), bone infection, aspirin-sensitive asthma, heart failure, liver problems, low blood calcium levels, high blood calcium levels caused by non-cancerous conditions (eg, overactive parathyroid gland), allergies, pregnancy, or breast-feeding. Tell your doctor if you have had or will be having chemotherapy or radiation treatment. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe kidney problems and you also have a certain type of cancer (multiple myeloma) or cancer that has moved into the bones from other parts of the body. Contact your doctor or pharmacist if you have any questions or concerns about this medicine.
SIDE EFFECTS that may occur while using this medicine include back pain, constipation, decreased appetite, diarrhea, dizziness, drowsiness, headache, mild cough or sore throat, mild muscle or joint aches, nausea, stomach pain or upset, tiredness, trouble sleeping, vomiting, weakness, or weight loss. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience blurred vision or other vision changes; change in the amount of urine produced; chest pain; confusion; decreased sense of touch; difficult or painful urination; fainting; fever, chills, or persistent cough or sore throat; flushing of the skin; irregular or slow heartbeat; jaw pain or swelling; mental or mood changes (eg, agitation, anxiety, depression); muscle cramps or spasms; numbness or tingling of the lips, tongue, fingers, or feet; pain, swelling, or redness at the injection site; redness, pain, or swelling of the eyes; severe bone, joint, or muscle pain (especially in the hip, groin, or thigh); severe or persistent dizziness; shortness of breath; swelling of the ankles or feet; swelling or soreness of the mouth or tongue; trouble swallowing; unusual bruising or bleeding; unusual tiredness or weakness; or very dry mouth or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include irregular heartbeat; mental or mood changes; muscle aches, cramps, pain, spasm, or weakness (especially of the face, feet, or hands); numbness or tingling of the lips, tongue, fingers, or feet; seizures; sluggishness; tremor; or unusual loss of appetite, nausea, vomiting or weakness.
IT TAKES AT LEAST A WEEK for the full therapeutic response to this medicine to occur. IF YOUR SYMPTOMS DO NOT IMPROVE or if they become worse, contact your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. DO NOT REUSE needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.