Depression Information & Discounts

Save on Depression medications with the free discounts below.

Depression is a commonly diagnosed condition that affects an increasing number of people worldwide, especially in first world countries. Anti-depression medication can be quite costly to refill on a regular basis. See our list of antidepressants below and claim your discount to immediately receive up to 75% off on your depression pills at your local pharmacy. Coupons may be printed or received via e-mail or text.

Related Depression Drug Discounts

Depression Information & Discounts

What is depression?

Depression, one of the most commonly diagnosed psychiatric disorders, is being diagnosed in increasing numbers in various segments of the population worldwide. Depression in the United States alone affects 17.6 million Americans each year or 1 in 6 people. Depressed patients are also at increased risk of type 2 diabetes, cardiovascular disease and suicide. Within the next twenty years depression is expected to become the second leading cause of disability worldwide and the leading cause in high-income nations, including the United States.

The causes of depression vary widely. Depression can be a result of life events, hormonal changes or imbalances, medical treatments, another illness that is not psychiatric (cancer, diabetes, chronic pain, tumors), and psychiatric syndromes. The best medication for depression depends on type, diet, other medications and other factors.

Types of Depression

There are several types of depression including major depressive disorder, dysthymia (less severe), minor depression (short-term), psychotic depression (depression with psychosis), postpartum depression (after childbirth), and seasonal affective disorder (SAD), which affects people that experience long periods of winter without much sunlight. Most of these disorders are treated with anti-depressants and/or therapy.

Depression is sometimes misdiagnosed as there are several disorders and conditions, physical or psychological that mimic the conditions of depression. Depression is often diagnosed by professionals that have little or no medical training. If depression persists even after treatment with depression medication and therapy, it is wise to have an examination conducted by a medical doctor as well.

How can I manage depression?

Depression will affect an individual’s everyday routine and activities. If symptoms of depression persist after a couple of weeks, and it’s starting to affect your social, work and family life, the individual should visit a doctor or mental health professional as soon as possible. (Read about symptoms for depression in “symptoms” section.) The sooner depression can be treated, the more effective the treatment is. It is preferable to visit a medical doctor first to be sure to rule out any physical causes of depression such as hormonal or thyroid disorder. Then schedule an appointment with a mental health specialist.

Depression Medication or Antidepressants

Your medical health professional will most likely prescribe depression medication or pills as treatment. There are several types of anti-depressants. (See “types of medication” to read about the different types of anti-depressants.) Antidepressants work on the neurotransmitters of the brain, especially serotonin, dopamine and norepinephrine, in order to regulate mood. Your doctor or health care professional will recommend the best anti-depression medication for you.  All depression medication must be taken for at least 4-6 weeks to be able to judge its full effect.


Both cognitive-behavioral therapy (CBT) and interpersonal behavioral therapy (IBT) may be used and are effective at treating depression. CBT helps patients to recognize and restructure their thought processes. Patients with depression may perceive most of their environment and interactions in a negative way. CBT helps patients to reverse these perceptions and see things in a positive and realistic light. CBT may also help patients to recognize and change behaviors that make depression worse. IBT helps people to understand and deal with troubled relationships that may cause depression or worsen it. Psychotherapy and medication in combination can be the best treatment for depression.

What are the different types of depression medication or antidepressants?


SSRIs & SSNIs are the newest anti-depressant medications. SSRIs or selective serotonin re-uptake inhibitors are used to treat depression, anxiety disorders, OCD and some eating disorders. They work by increasing the level of serotonin available in the synaptic gap in the brain. SSNIs or serotonin-norepinephrine re-uptake inhibitors work like SSRIs, but additionally raise the level of the neurotransmitter norepinephrine in the brain. SSNIs are also used to treat ADHD. SSRIs and SSNIs are considered to be the best depression medication in some cases, as they have less severe side effects than other antidepressants. Side effects of SSNIs include: loss of appetite, weight loss, loss of libido, sexual dysfunction, drowsiness, dizziness, loss of sleep, headaches and urinary retention.


The prescription of tricyclics or TCAs has been largely replaced by SSRIs and SSNIs as a depression medication due to less severe side effects. TCAs are antidepressants that are also used to treat anxiety, smoking addiction, migraines, OCD and PTSD among others. Tricyclics work similarly to SSRIs and SSNIs by increasing serotonin and norepinephrine synaptic levels in the brain. TCAs also inhibit other receptors in the brain such as sigma, histamine, and muscarinic acetylcholine receptors. They also potentially inhibit sodium channels and calcium channels. This is why TCAs have higher occurrences of side effects and overdoses. Side effects include dry mouth, dry nose, blurred vision, constipation, memory impairment, dizziness, sweating and irregular heart rate, among others.


MAOIs are an anti-depression medication usually used to treat depression as a last resort due to their potentially fatal interactions with other medications and certain foods. They are also used to treat Parkinson’s Disease and other disorders. MAOIs work by inhibiting the activity of monoamine oxidase enzymes, therefore preventing the breakdown of monoamine neurotransmitters and increasing their availability in the brain. Monoamine neurotransmitters include serotonin, melatonin, epinephrine, norepinephrine, phenethylamine and dopamine. MAOIs can be an extremely costly anti-depressant drug.  Patients taking MAOIs should avoid cheese and red wine. MAOIs can cause severe and potentially fatal side effects when they interact with certain foods, medication and SSRIs.

Atypical Antipsychotics

Atypical antipsychotic drugs or second generation antipsychotics are anti-depression medications that act on the dopamine receptors in the brain to help calm the intensity of acute manic episodes or severe depression. They are also used to treat bipolar disorder, schizophrenia, OCD, dementia and anxiety. Side effects of atypical antipsychotics vary depending on the drug. 

What are the symptoms of depression?

Symptoms of depression include severe feelings of sadness, anxiety, hopelessness, guilt, irritability and worthlessness. An individual with depression may also experience loss of appetite, insomnia and loss of energy. Depression affects a person’s ability to complete everyday activities. They may miss several days of work and lose interest in normally pleasurable activities. They may have trouble making decisions or concentrating. Thoughts of suicide may be present.

Depression Drug Information

Amitriptyline Information

Amitriptyline is a tricyclic or TCA antidepressant. It is a depression pill to be taken orally with a glass of water. Tricyclics work similarly to SSRIs and SSNIs by increasing serotonin and norepinephrine synaptic levels in the brain. TCAs also inhibit other receptors in the brain such as sigma, histamine, and muscarinic acetylcholine receptors. Follow your doctor’s instructions when taking this medication. Side effects include confusion, irregular heartbeat, fever, nausea, vomiting, constipation and diarrhea, among others. Always provide your doctor with a list of medications you are currently taking before taking amitriptyline. Claim your free amitriptyline coupon below or check our site for discounts on other tricyclic depression pills.

Citalopram Information

Citalopram is an antidepressant available as a pill or oral solution. Citalopram is an SSRI, or selective serotonin re-uptake inhibitor, that increases the availability of serotonin in the synaptic gap in the brain. It can also be used to treat anxiety, PMDD, OCD and eating disorders. Side effects of citalopram include drowsiness or dizziness, confusion, irregular heartbeat, nausea, headache and change in appetite or sex drive. Always provide your doctor with a list of medications you are currently taking before taking citalopram. Don’t forget to claim your coupon for citalopram or check our site for discounts on other SSRI depression medications.

Effexor XR Information

Effexor XR and Cymbalta depression medications in pill form. They are SNRIs or serotonin-norepinephrine re-uptake inhibitors which work by increasing the levels of serotonin and norepinephrine in the synaptic gap in the brain. Take this medication with a full glass of water and follow instructions given by your doctor. Side effects of SNRIs include weight loss, loss of appetite, loss of sleep, drowsiness, dizziness, diminished libido, anxiety, elevated pulse and blood pressure, among others. Claim your free Effexor XR coupon below or search our site for free coupons on other SNRI depression medications.

Nardil Information

Nardil, or phenelzine in its generic form, is a MAOI anti-depressant pill or tablet. It may also be used to treat Parkinson’s Disease. MAOIs work by inhibiting the activity of monoamine oxidase enzymes, therefore preventing the breakdown of monoamine neurotransmitters and increasing their availability in the brain. Take this depression pill orally with a glass of water. Follow instructions given by your doctor or pharmacist. Avoid cheese, smoked meats and alcohol when taking this drug. Ask your doctor for a list of foods and substances to avoid. Side effects of Nardil include confusion, nervousness, difficulty sleeping, constipation, fever, clammy skin and a change in blood pressure or heart rate, among others. Don’t forget to claim your free Nardil coupon or check our site for other discounts on MAOI antidepressants.

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About Our Savings: is a discount pharmacy service, partnered with a leading pharmacy benefit manager. We negotiate lower prices on prescription medications, that we pass on to our members for free. There is no cost to use our cards and coupon, and anyone can take advantage of our discounts, regardless of healthcare coverage.

Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.