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Estradiol Coupon & Discounts

Save on Estradiol at your pharmacy with the free discount below.

Estradiol is an effective tool to treat the symptoms of menopause, including hot flashes, vaginal dryness, burning and irritation. Estradiol is also effective at preventing osteoporosis in post-menopausal women and replaces necessary estrogen as part of a cancer treatment for women and men. Available in patch f ... Read more

Estradiol Discount

Savings with HelpRx discount up to:

75% Off

on Estradiol

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*The discount percent is an estimate based off recent cardholder data. Valid as of May 24, 2018

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Estradiol Information:

What is estradiol?

Estradiol is the generic name for medication used to replace the primary female human sex hormone and steroid produced by the ovaries and necessary for many processes throughout the female body. Estradiol is important for the regulation of estrous and female menstrual cycles.  While it is important for the development and maintenance of reproductive tissues, it also provides significant benefits in other tissues, including bone. Because males require estrogen for essential functions, although at much lower levels relative to females, estradiol is also an effective tool for some male therapies. Estradiol is produced naturally through female ovary follicles and in other hormone-producing and non-endocrine tissues, such as liver, fat, adrenal, breast and neural tissues. 

How do I take estradiol?

You can save on the estradiol retail cost by purchasing your medications at your local pharmacy using our free estradiol coupon or discount card. You should discuss the proper use of estradiol with your doctor or pharmacist, and you may also read through the “What is Estradiol” information packet included with each estradiol prescription.

You should take estradiol exactly as it was prescribed to you by your healthcare practitioner. You may be prescribed estradiol pills or a transdermal patch. Patches are usually applied once or twice per week while tablets are usually taken once per day. Do not take estradiol in large amounts, smaller amounts, or for longer periods than prescribed. Your doctor will check your progress approximately every three to six months. During that period, you should perform a breast examination on a monthly basis to check for lumps. 

Before taking estradiol, tell your doctor if:

  • You are pregnant, are planning to become pregnant, or are breastfeeding.
  • You have unusual vaginal bleeding that has not been checked by a doctor.
  • You have liver disease.
  • You have a bleeding or clotting disorder.
  • You have a recent history of heart attack or stroke.
  • You have a history of hormone-dependent cancer.
  • You have ever had a blood clot, particularly in your lung or lower body.
  • You are allergic to any medications or food dyes.
  • You have heart disease.
  • You have diabetes, lupus, high blood pressure, high cholesterol, a family history of coronary artery disease, have had a hysterectomy, smoke, or are overweight.
  • You have a history of jaundice caused by pregnancy or birth control pills.
  • You have a thyroid disorder.
  • You have asthma.
  • You have kidney disease.
  • You have epilepsy or other seizure disorder.
  • You have migraines.
  • You have porphyria.
  • You have endometriosis or uterine fibroid tumors.
  • You have gallbladder disease.
  • You have high or low levels of calcium in your blood.
  • You have had your uterus removed.

What are the possible side effects of taking estradiol?

The following is not an all-inclusive list of the potential side effects of estradiol. You should call your doctor at once if you experience heart attack symptoms (chest pain or pressure spreading to your jaw or shoulder, nausea or sweating), signs of a stroke (sudden numbness or weakness, sudden severe headache, slurred speech, vision or balance problems), signs of a blood clot in the lung (chest pain, sudden cough, wheezing, rapid breathing, or coughing up blood); or signs of a blood clot in your leg (pain, swelling, warmth or redness in either or both legs); swelling or tenderness in your stomach; jaundice (yellowing of your skin or your eyes); unusual vaginal bleeding; a lump in your breast; fluid retention; or high levels of calcium in your blood (numbness or tingly feelings around your mouth, changes in your heart rate, muscle tightness or contractions, and overactive reflexes).

Other side effects from taking estradiol may not be emergency issues, but should be discussed with your doctor. These include breast pain, headache, vaginal itching or discharge, changes in your periods, thinning scalp hair, nausea, vomiting, or stomach cramps.

What if I forget to take a dose of estradiol?

If you forget to take your estradiol pills, you should take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your normal dosing schedule. Do not take extra medicine or double doses.

What happens if I overdose on estradiol?

If you believe you may have overdosed on estradiol, contact your prescribing doctor or emergency medical services. Overdose symptoms can include nausea, vomiting or vaginal bleeding.


Talk to your doctor about eating grapefruit, drinking grapefruit juice or taking any grapefruit-based products while taking estradiol, as they may interact and cause unwanted side effects.

Estradiol may increase your risk of developing conditions which may lead to uterine cancer. Contact your doctor at once if you experience unusual vaginal bleeding after taking estradiol.

Brand Names

Estradiol is the generic name for the female hormone replacement drug. Estradiol comes in multiple forms and is marketed under different names depending on the form used.

Gel form: Estrogel, Estrasorb, Estraderm

Oral form: Estrace, Estrofem, Femtrace, Estrofem, Progynova

Transdermal patches: Alora, Climara, Minivelle, Vivelle-Dot, Menostar, Estraderm

Topical spray: EvaMist

Ointments: Divigel, Estrasorb Topical, Elestrin

Injections: Estradiol Benzoate, Estradiol Cypionate, Estradiol Valerate

Vaginal ointment: Estrace Vaginal Cream

Vaginal ring: Estring, Femring.

Vaginal tablet: Vagifem

To reduce the high retail costs for estradiol pills, take advantage of our free estradiol coupon or discount card to save up to 77% at your local pharmacy. Also search our site for other types of estradiol medication and find discount coupons for up to 75% off.

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Estradiol Information:

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About Our Savings: is a discount pharmacy service, partnered with a leading pharmacy benefit manager. We negotiate lower prices on prescription medications, that we pass on to our members for free. There is no cost to use our cards and coupon, and anyone can take advantage of our discounts, regardless of healthcare coverage.

Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.