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Fluorouracil Coupon & Discounts

Save on Fluorouracil at your pharmacy with the free discount below.

Topical fluorouracil is a drug used in the treatment of actinic keratosis and other precancerous or cancerous lesions and is a dispensed as a cream or a liquid for home use. Injectable fluorouracil is prescribed to treat certain cancers and is administered intravenously in a healthcare facility. Fluorouracil co ... Read more

Fluorouracil Discount

Savings with HelpRx discount up to:

75% Off

on Fluorouracil

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*The discount percent is an estimate based off recent cardholder data. Valid as of May 23, 2018

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Fluorouracil Information:

What is fluorouracil?

Fluorouracil, an antimetabolite drug, works by killing fast-growing cancerous and precancerous cells. The topical formula, an antineoplastic dermatological medication, is prescribed to treat actinic (solar) keratosis caused by overexposure to sunlight or UV radiation; it may also be prescribed to treat other cancerous or precancerous skin conditions, such as basal cell carcinoma. Injectable fluorouracil is a chemotherapy medication used in the treatment of breast, pancreatic, stomach, colon, and rectal cancers. 

How do I take fluorouracil?

Topical fluorouracil is administered as a cream or a solution and usually applied to the affected site twice a day. The strength of the medication and the frequency of application will depend on the condition being treated and the patient’s medical profile. Follow the application instructions exactly. Apply the prescribed amount using a finger or applicator and gently massage it into the skin. Wash your hand after application. Do not let this medications come in contact with the eyes, nose, mouth, or eyelids. Injectable fluorouracil will be administered intravenously in a medical facility by a qualified healthcare provider.

Before taking fluorouracil, tell your doctor if:

  • You are allergic to fluorouracil or any of the ingredients in the medication
  • You are pregnant, planning a pregnancy, or are nursing a child
  • You are taking any prescription or non-prescription medications, vitamins, or supplements
  • You have, or have had, DPD (dihydropyrimidine dehydrogenase enzyme deficiency)
  • You are taking, or have taken, chemotherapy medications or medications that suppress the immune system
  • You have an infection
  • You have had radiation therapy using other chemotherapy drugs
  • You have, or have had, liver or kidney disease

What are the possible side effects of taking fluorouracil?

Some people have reported side effects after using the fluorouracil drug. Less severe symptoms include redness, irritation, burning, pain, skin discoloration, crusting, or soreness at the application or injection site; the injectable form may also cause confusion, dizziness, dry and cracked skin, eye sensitivity to light, teary eyes, hair loss, headache, loss of appetite, nausea, redness, pain, unusual fatigue or weakness, or vision changes. If any of these conditions persist or worsen, contact your healthcare provider.

Severe side effects requiring immediate medical attention include signs of an allergic reaction (rash, hives, itching, peeling or blistered skin; swelling of the face, mouth, lips, throat, or tongue; fever; hoarseness; difficulty breathing or swallowing); bloody diarrhea; chills; severe stomach pain; vomiting; chest pain; coughing up or vomiting blood or material that looks like coffee grounds; nosebleed; changes in urine color; red or tarry stools; mouth or throat sores; swelling, pain, redness, or peeling of skin on the palms and soles of the feet; unusual bleeding or bruising.

What if I forget to take a dose of fluorouracil?

If you forget to apply topical fluorouracil, do so as soon as your remember and are able. However, if it is almost time for the next scheduled application, skip the one missed and resume the regular schedule. Do not increase the amount applied or change the regimen to make up for one that was missed. Because the injectable form is administered in a healthcare facility, missing a dose is unlikely.

How do I store fluorouracil?

Keep topical fluorouracil sealed in its original tube or bottle, out of the reach of children and away from extremes of temperature and humidity. Do not allow the cream or liquid to freeze. Dispose of any unused medication according to the instructions of your pharmacist. Fluorouracil injectable will be stored and administered in a medical facility.

What happens if I overdose on fluorouracil?

Fluorouracil topical is for external use only. If it is accidentally ingested, contact the Poison Control Center at 1-800-222-1222. If the individual has stopped breathing or lost consciousness, contact Emergency Services at 911. 


Topical fluorouracil is for external use only. Contact your doctor if you become pregnant. Avoid prolonged exposure to UV light and sunlight while using this medication. Keep fluorouracil away from the mouth, nose, eyelids, and eyes. Injectable fluorouracil should be administered only in a medical facility.


Brand Names

Fluorouracil is the generic name for an antimetabolite used to treat cancerous and precancerous skin lesions and in the treatment of certain cancers; it is also marketed as Tolak, Adrucil, Carac Cream, Efudex Cream, Fluoroplex Cream, and Efudex Solution. Do not substitute one for another without written medical permission. To help keep the fluorouracil price manageable, take advantage of the fluorouracil coupons from HelpRx and save up to 75% at your favorite pharmacy. In addition, HelpRx also provides a drug discount card you can request by clicking the “Free Card” button at the top of any page on the site. This card is good for discounts of as much as 75% at local pharmacies for hundreds of other generic and name brand medications.

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Fluorouracil Information:

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About Our Savings: is a discount pharmacy service, partnered with a leading pharmacy benefit manager. We negotiate lower prices on prescription medications, that we pass on to our members for free. There is no cost to use our cards and coupon, and anyone can take advantage of our discounts, regardless of healthcare coverage.

Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.