This medicine is a monoclonal antibody used to treat certain types of breast cancer alone or in combination with other medicines. It is also used in combination with other medicines to treat certain types of stomach or gastroesophageal junction (where the esophagus meets the stomach) cancer in certain patients.
Follow the directions for using this medicine provided by your doctor. This medicine is administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. DO NOT USE THIS MEDICINE if it is cloudy or discolored, contains particles after it is mixed, or if the vial is cracked or damaged. STORE THIS MEDICINE as directed on the prescription label. KEEP THIS MEDICINE, as well as syringes and needles, out of the reach of children and pets. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor immediately.
WARNING: USE OF THIS MEDICINE may lead to serious heart problems, including heart failure. The risk may be greater in patients who use anthracyclines (eg, doxorubicin) with this medicine. Your doctor will perform heart function tests before you start this medicine and periodically while you use it. Contact your doctor right away if you develop irregular heartbeat; persistent cough; shortness of breath; sudden, unexplained weight gain; or swelling of the hands, ankles, or feet. SOME PATIENTS HAVE EXPERIENCED serious and sometimes fatal infusion reactions and lung problems with this medicine. These problems, if they occur, usually happen while the medicine is being given, or within 24 hours after the dose. Tell your doctor right away if you develop swelling of the mouth, face, lips, tongue, or throat; fainting; rash; severe dizziness or lightheadedness; new or worsening shortness of breath or trouble breathing; unusual hoarseness; or wheezing. THIS MEDICINE MAY CAUSE SERIOUS HARM TO THE FETUS if used during pregnancy. If you are able to become pregnant, you must use an effective form of birth control while you use this medicine and for at least 6 months after you stop using it. If you have questions about effective birth control, talk with your doctor. If you think you may be pregnant, contact your doctor right away. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are also using anthracyclines (eg, doxorubicin) or antineoplastic agents (eg, cyclophosphamide). DO NOT START OR STOP ANY MEDICINE without doctor or pharmacist approval. TELL YOUR DOCTOR if have had a reaction (eg, rash; hives; itching; difficulty breathing; shortness of breath; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing) to a previous dose of this medicine. Inform your doctor of any other medical conditions, including a history of breathing or lung problems, heart problems (eg, heart failure), high blood pressure, chronic infections, bone marrow problems (eg, low red or white blood cell counts, low platelet counts), kidney problems, allergies, pregnancy or if you are able to become pregnant, or breast-feeding. Tell your doctor if you have received radiation treatment. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
SIDE EFFECTS that may occur while using this medicine include back, bone, or joint pain; change in taste; diarrhea; dizziness; fingernail or toenail changes; headache; loss of appetite; mild fever or chills; mild muscle pain; nausea; nose, sinus, or throat irritation; runny or stuffy nose; stomach pain or upset; tiredness; trouble sleeping; vomiting; or weight loss. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience burning, numbness, or tingling sensation; calf or leg pain, redness, swelling, or tenderness; change in the amount of urine produced; chest pain; dark, tarry, or bloody stools; depression; difficult or painful urination; fainting; fast or irregular heartbeat; muscle pain, weakness, or cramping; new or worsening cough, shortness of breath, or trouble breathing; pain, redness, or swelling at the injection site; pain, swelling, or sores of the mouth or tongue; severe or persistent dizziness, headache, or lightheadedness; severe or persistent nausea, vomiting, or diarrhea; skin infection (eg, skin discharge, redness, swelling, or warmth); sudden, unexplained weight gain (eg, more than 5 pounds in 24 hours); swelling of the hands, feet, or ankles; symptoms of infection (eg, severe or persistent fever, chills, or sore throat); trouble swallowing; unusual bruising or bleeding (eg, nosebleed); unusual tiredness or weakness; weakness; or wheezing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
If overdose is suspected, contact your local poison control center or emergency room immediately.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.