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Otrexup Coupon & Discounts

Save on Otrexup at your pharmacy with the free discount below.

Otrexup is a once weekly prescription injection that treats rheumatoid arthritis and juvenile arthritis in patients who have tried non-steroidal anti-inflammatory drugs (NASIDs) but were ineffective at curbing symptoms. This drug can be expensive without an Otrexup copay card or patient assistance. The average ... Read more

Otrexup Discount

Savings with HelpRx discount up to:

75% Off

on Otrexup

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*The discount percent is an estimate based off recent cardholder data. Valid as of May 22, 2018

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Otrexup Information:

What is Otrexup?

Otrexup is an injectable treatment that is effective at treating adults and children with arthritis. Prescription Otrexup injections are recommended to patients who have been treated with non-steroidal anti-inflammatory drugs (NASIDs), but were not able achieve arthritis relief. Otrexup contains the active ingredient methotrexate that works by reducing inflammation in joints and muscles to relieve symptoms like stiffness, swelling, tenderness, weakness, and fatigue. It is Important to take Otrexup as directed to achieve maximum arthritis relief.

How do I take Otrexup?

Patient should only self-infect Otrexup with the guidance of a health care professional. If you are cleared to use Otrexup at home, check the viewing window of the injector to make sure that the liquid has a yellow consistency. Choose an injection site around the abdomen or thigh region. It is important not inject Otrexup in the arms or other regions not listed. Inject Otrexup cleaning the injection site with alcohol and by removing the cap of the injector. Place the needle against the thigh or stomach region, and firmly push the device against the injection site until you hear a click. Hold the Otrexup injector for 3 seconds and remove once the viewing window shows a red flag. If you have any doubts about how to use Otrexup, contact your pharmacy for patient assistance.

Before taking Otrexup, tell your doctor if:

  • You are pregnant or plan to become pregnant
  • You are breastfeeding or plan to breastfeed
  • You have history of alcohol abuse
  • You have liver problems
  • You have an immunodeficiency syndrome
  • You are taking other medications

What are the possible side effects of taking Otrexup?

There are possible side effects associated with Otrexup like chronic ulcerative stomatitis, reduction of white blood cells, abdominal distress, fatigue, chills, fever, dizziness, and infections. Otrexup suppresses the immune system, and this may make it difficult to fight serious infections. 

What if I forget to take a dose of Otrexup?

If you forget to administer Otrexup, skip the missed dose and remember to take it during you next scheduled injection. Do not double up on Otrexup to make up for a missed dose. 

How do I store Otrexup?

Store Otrexup in a room with a temperature between 68 to 77 degrees Fahrenheit. Do not expose the medication to extreme head, cold, or excess moisture. Keep Otrexup out of reach of children. 

What happens if I overdose on Otrexup?

If you accidently overdose on Otrexup, contact immediate medical assistance at 911 or call poison control at 1 (800) 222-1222.


Otrexup may cause serious health complications like fertility problems, certain cancers, and tissue problems. Make sure to discuss all the risks and benefits of using Otrexup with your doctor.


Brand Names

Otrexup is a prescription medication that is approved to treat arthritis in adults and children. There is currently not a generic version of Otrexup available. Generic medications off contain the same or similar active ingredients to name brand medications, and are approved by the FDA to safety and effectiveness. To help lower high prescription costs, we encourage patients to use an Otrexup coupon on our page for up to 75% off at the pharmacy by clicking ‘Claim Discount’ on our page. 

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“The price for my prescription has gone up the past year and paying the out of pocket cost was getting increasingly difficult. Now, through HelpRx I’ve saved hundreds! Thank you HelpRx” - Janet Larsen - Austin, TX

Otrexup Information:

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About Our Savings: is a discount pharmacy service, partnered with a leading pharmacy benefit manager. We negotiate lower prices on prescription medications, that we pass on to our members for free. There is no cost to use our cards and coupon, and anyone can take advantage of our discounts, regardless of healthcare coverage.

Our savings assurance of “up to 75% off” comes from historical data from actual claims. This data includes savings for both brand name and generic medications.